Neurobiology of Disease Suppression of Inflammation with Conditional Deletion of the Prostaglandin E2 EP2 Receptor in Macrophages and Brain Microglia
نویسندگان
چکیده
Jenny U. Johansson,1 Suraj Pradhan,1,5 Ludmila A. Lokteva,1,2 Nathaniel S. Woodling,1,5 Novie Ko,6 Holden D. Brown,1 Qian Wang,1 Christina Loh,3 Egle Cekanaviciute,1,5 Marion Buckwalter,1,4 Amy B. Manning-Boğ,6 and Katrin I. Andreasson1 Departments of 1Neurology and Neurological Sciences, 2Molecular and Cellular Physiology, 3Microbiology and Immunology, and 4Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, 5Neurosciences Graduate Program, Stanford University, Stanford, California 94305, and 6Center for Health Sciences, SRI International, Menlo Park, California 94025
منابع مشابه
Suppression of inflammation with conditional deletion of the prostaglandin E2 EP2 receptor in macrophages and brain microglia.
Prostaglandin E2 (PGE2), a potent lipid signaling molecule, modulates inflammatory responses through activation of downstream G-protein coupled EP(1-4) receptors. Here, we investigated the cell-specific in vivo function of PGE2 signaling through its E-prostanoid 2 (EP2) receptor in murine innate immune responses systemically and in the CNS. In vivo, systemic administration of lipopolysaccharide...
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